![]() Even though the role of gyrB and parE in quinolone resistance is unclear, the subunits gyrB and parE were included as zoliflodacin, a promising new drug to treat N. ![]() In this study, we evaluated if there was evidence of HGT in the genes gyrA/gyrB and parC/parE responsible for fluoroquinolone resistance. The genetically related commensal Neisseria act as a reservoir of resistance genes, and horizontal gene transfer (HGT) has been shown to play an important role in the genesis of resistance to cephalosporins and macrolides in N. 2Department of Medicine, University of Cape Town, Cape Town, South AfricaĪntimicrobial resistance in Neisseria gonorrhoeae is an important global health concern.1Department of Clinical Sciences, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.Sheeba Santhini Manoharan-Basil 1 *, Natalia González 1, Jolein Gyonne Elise Laumen 1 and Chris Kenyon 1,2
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